Introduction: Leishmaniasis is an infectious disease currently threatens 350 million people in 88 countries. Lupoid leishmaniasis occurs as a result of the host response, in which despite an intensified hypersensitivity the cell mediated immunity cannot sterilize lesions. A chronic granulomatous inflammation remains active for a long time. To summarize the articles published about Lupoid leishmaniasis. Materials and Methods: a systematic web base search was conducted in PubMed up to July 2015. We included articles with available abstract in English language. Manual searching was done within the reference list of articles. Results: Two reviewers independently reviewed and assessed eligibility criteria, assessed quality, and extracted data. Conclusion: Some patients have periods of relapse and remission at the site of inoculation of parasites and others suffer from chronic injury for years. In the case of effective disease treatment several studies have been conducted, so far, no satisfactory results have been achieved.
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