Evaluation of Plasma Soluble Human Leukocyte Antigen-G Level in Asthmatic Children Aged 2 to 14 Years Old in Ghaem Hospital

Document Type : Original Article


1 Patient Safety Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Debrecen University, Hungary


Introduction: To evaluate serum level of plasma soluble human leukocyte antigen-G (sHLA-G) in asthmatic children aged 2 to 14 years old.

Materials and Methods: This prospective, cross-sectional study was conducted on 83 patients aged 2-14 years in Ghaem Hospital, Mashhad, Iran, during 2013-2015. The participants were divided into two groups of asthmatic patients (n=29) and healthy children (n=54). Blood samples were drawn from the case (on admission) and control groups.

Results: In the control group, 33 cases were male (61.1%) and 21 (38.9%) were female. In the case group, 18 patients (62.1%) were male and 11 (37.9%) were female (P=0.65). Mean ages of the control and case groups were 4.75±3.57 and 4.93±2.38 years, respectively (P=0.17). Mean serum levels of sHLA-G in the control and case groups were 396.51±279 U/ml and 184.58±302.08 U/ml, respectively (P<0.001).

Conclusion:Serum level of sHLA was significantly lower in the asthmatic children compared to healthy ones.