Comparison of Anti-Saccharomyces Cerevisiae Antibodies (ASCA) in Behcet’s Disease Patients with Three Groups of Oral Aphthosis, other Rheumatologic Diseases and Healthy Volunteers
Introduction: Behcet’s Disease (BD) is a general and progressive vasculitis and involves various organs. Its main etiology is not yet understood; however, immunologic and infectious causes and genetic predisposition have been proposed. Saccharomyces Cerevisiae is a type of yeast which is used in the bread and wine industries. Antibodies against this yeast have a well-proven role in inflammatory bowel diseases. The aim of the present study was to assess the frequency of Anti-Saccharomyces Cerevisiae Antibody (ASCA) and its relation to clinical symptoms and disease activity index in patients afflicted by BD. Materials and Methods: Serum ASCA levels, determined by ELISA, were Studied in Behcet’s disease along with oral aphthosis, other rheumatologic diseases and healthy volunteers (n=30 in each group). In the BD group the disease activity index and different clinical symptoms were recorded during the study course. Results:Serum level of ASCA in the four studied groups of BD, oral aphthosis, other rheumatologic disease and healthy volunteers was 9.18±9.69, 10.90±10.40, 11.29±17.96 and 8.86±5.31IU/ml, respectively; indicating no meaningful difference (p=0.811). The ASCA titer was not related to Behcet’s disease severity (p=0.399). Serum level of ASCA in BD patients with oral aphthosis or with gastrointestinal symptoms was significantly higher than the other Behcet’s Disease patients (p=0.012, p=0.014). Conclusion: ASCS is not a valuable test for distinguishing BD from recurrent oral aphthosis or other connective tissue disorders. It also cannot be used for determining disease severity. However, it has a higher level in BD patients with oral aphthous ulcers and gastrointestinal symptoms.
Kerdari, S., Jokar, M. H., Mirfeizi, S. Z., & Yahyavi, V. (2015). Comparison of Anti-Saccharomyces Cerevisiae Antibodies (ASCA) in Behcet’s Disease Patients with Three Groups of Oral Aphthosis, other Rheumatologic Diseases and Healthy Volunteers. Journal of Patient Safety & Quality Improvement, 3(3), 257-261. doi: 10.22038/psj.2015.4565
MLA
Saeed Kerdari; Mohammad Hassan Jokar; Seyedeh Zahra Mirfeizi; Vahid Yahyavi. "Comparison of Anti-Saccharomyces Cerevisiae Antibodies (ASCA) in Behcet’s Disease Patients with Three Groups of Oral Aphthosis, other Rheumatologic Diseases and Healthy Volunteers". Journal of Patient Safety & Quality Improvement, 3, 3, 2015, 257-261. doi: 10.22038/psj.2015.4565
HARVARD
Kerdari, S., Jokar, M. H., Mirfeizi, S. Z., Yahyavi, V. (2015). 'Comparison of Anti-Saccharomyces Cerevisiae Antibodies (ASCA) in Behcet’s Disease Patients with Three Groups of Oral Aphthosis, other Rheumatologic Diseases and Healthy Volunteers', Journal of Patient Safety & Quality Improvement, 3(3), pp. 257-261. doi: 10.22038/psj.2015.4565
VANCOUVER
Kerdari, S., Jokar, M. H., Mirfeizi, S. Z., Yahyavi, V. Comparison of Anti-Saccharomyces Cerevisiae Antibodies (ASCA) in Behcet’s Disease Patients with Three Groups of Oral Aphthosis, other Rheumatologic Diseases and Healthy Volunteers. Journal of Patient Safety & Quality Improvement, 2015; 3(3): 257-261. doi: 10.22038/psj.2015.4565
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