Comparing the effect of intravenous tranexamic acid by continuous infusion method with a separate intravenous method on bleeding after the simultaneous bilateral knee Arthroplasty

Document Type : Original Article

Authors

1 Department of Orthopedic, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

2 Department of Anethesiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

3 Department of Community Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

4 Department of Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

5 School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

10.22038/psj.2025.83919.1447

Abstract

Introduction:
Significant postoperative bleeding is linked to total knee arthroplasty (TKA), and tranexamic acid (TXA), a strong medication with strong anti-fibrinolytic properties, can lessen surgical bleeding. This study compared the effects of continuous intravenous tranexamic acid infusion with a separate intravenous approach concerning postoperative bleeding in synchronic bilateral knee arthroplasty.
 
Materials and Methods:
Hemoglobin changes (24 and 48 hours after surgery), the gases used during the procedure, and the amount of bleeding were assessed in 120 patients who had simultaneous bilateral knee replacement surgery and received intravenous tranexamic acid by continuous infusion (n = 40), single intravenous injection (n = 40), or without injection (n = 40).
 
Results:
In 120 patients who underwent simultaneous bilateral knee replacement surgery and received intravenous tranexamic acid by continuous infusion (n = 40), single intravenous injection (n = 40), or no injection (n=40), hemoglobin changes (24, 48 hours postoperatively), the gases used during the procedure, and the extent of bleeding were evaluated.
 
Conclusion:
The current study's findings demonstrated that the rate of postoperative hemorrhage and the quantity of gases used in continuous infusion and stat intravenous were reduced compared to the control group. Furthermore, the continuous infusion strategy decreased postoperative hemorrhage and gas consumption compared to the stat intravenous approach.

Keywords

Main Subjects

References

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Journal of Patient Safety & Quality Improvement
Volume 12, Issue 4
October 2024
Pages 197-202

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