Prevalence of Nasal Carriage for Staphylococcus Aureus in Chronic Spontaneous Urticaria and Its Association with Disease Control Status

Document Type : Research Paper

Authors

1 Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2 Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Affiliation

3 Department of Dermatology, Mashhad University of Medical Sciences, Mashhad, Iran Affiliation

4 Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Affiliation

5 Mashhad University of Medical Sciences, Mashhad, Iran

6 Mashhad University of Medical Sciences, Mashhad, Iran Affiliation

10.22038/psj.2024.78952.1427

Abstract

Introduction:
Chronic spontaneous urticaria (CSU) is characterized by the appearance of urticaria for more than six weeks and no underlying condition is found. There is some evidence that chronic infections are more frequent among CSU patients. This study was  designed to compare the prevalence of nasal carriage of Staphylococcus aureus in urticaria patients and healthy control.
 
Materials and Methods:
A population of 60 CSU cases and 30 healthy controls not working in a health-care-related environment were  recruited. Nasal swabs and cultures were  done for all individuals. The patients filled out Urticaria Control Test . S. aureus-positive CSU patients received treatment for their S. aureus colonization.
Results:
About 26.7% (n=16) of CSU cases and 6.7%(n=2) of healthy controls were nasal carriers of S. aureus, and the difference in the frequency was statistically significant (P = 0.025). Among S. aureus positive CSU patients 81.3% (n=13)  and among  S. aureus negative patients 84.1% (n=37)  had a poorly controlled disease.The difference between these two groups was not statistically significant (P = 0.99).
 Conclusion:
Nasal carriage of S. aureus is more frequent among CSU patients compared to healthy controls. However, being a carrier of S. aureus does not have a detrimental effect on the disease control status of CSU patients.

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