Document Type : Original Article
Department of Internal Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Bachelor of Science, Ferdowsi University of Mashhad, Mashhad, Iran.
Due to the spreading of coronavirus infection in 2019 (COVID-19) throughout the world, tracking cell blood count (CBC) of moderate to severe COVID-19 patients could provide new insights for the prognosis prediction.
Materials and Methods:
In this observational-retrospective study, D-dimer and CBC documents of 320 confirmed COVID-19 patients hospitalized in Shamsoshomus Clinic, Mashhad, Iran, were evaluated. Receiver operation characteristics (ROC) curve was analysed to determine specificity and sensitivity of D-dimer and hematological indices, including white blood cell (WBCs), lymphocytes, monocytes, eosinophil, red blood cell width (RDW), platelets (PLT), and mean of platelet volume (MPV).
This study included 157 (49.1%) male and 163 (50.3%) female COVID-19 patients between 14 to 96 years old. According to their status in the duration of hospitalization, patients were considered in the good outcome group (N=215) and poor outcome group (N=105). A significant difference was observed in D-dimer, WBCS, PMN, Lymph, monocytes, eosinophil, and RDW between the two groups (P<0.001). The highest sensitivity and the lowest specificity belonged to RDW (99%, 4%), WBCs (98%, 4%), PMN (99%, 11%) and D-dimer (96%, 42%). D-dimer indicated a significant association with WBCs, PMN, and RDW (P<0.05).
The present study revealed that WBCs and RDW might be recommended for the COVID-19 prognosis prediction due to their high comparable sensitivity to D-dimer.