Warfarin interactions: a letter to editor

Document Type : Letter to the editor

Authors

Department of Emergency Medicine. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Today, with the advances in the treatment of cardiovascular patients such as intravascular stents, cardiac valves and intraventricular pacing and heart transplantation, many patients require the use of anticoagulants such as warfarin, sprain, Plavix, osvix, Ticlopidine and other drugs. Drugs that cause warfarin toxicity can also disrupt patients' hemodynamic conditions and can be dangerous in older people with underlying diseases. This review study examines some of the most common drug interactions with warfarin. Considering the increasing use of herbal medicine by patients, the importance of educating patients on warfarin is crucial, as many of these drug interactions are dangerous and life-threatening. Due to widespread drug interactions with warfarin and comprehensive use of non-prescription drugs in our country, accurate education and training of warfarin users is of paramount importance.
Today, with the advances in the treatment of cardiovascular patients such as intravascular stents, cardiac valves and intraventricular pacing and heart transplantation, many patients require the use of anticoagulants such as warfarin, sprain, Plavix, osvix, Ticlopidine and other drugs. Drugs that cause warfarin toxicity can also disrupt patients' hemodynamic conditions and can be dangerous in older people with underlying diseases. This review study examines some of the most common drug interactions with warfarin. Considering the increasing use of herbal medicine by patients, the importance of educating patients on warfarin is crucial, as many of these drug interactions are dangerous and life-threatening.

Keywords

References

  1. Dong YH, Bykov K, Choudhry NK, Donneyong MM, Huybrechts KF, Levin R, et al. Clinical Outcomes of Concomitant Use of Warfarin  and Selective  Serotonin  Reuptake
     Inhibitors: A Multidatabase Observational Cohort Study. J Clin Psychopharmacol. 2017 Apr; 37(2):200-209.
  2. Lane MA, Zeringue A, McDonald JR. Serious bleeding events due to warfarin and antibiotic co-prescription in a cohort of veterans. Am J Med. 2014 Jul;127(7):657-663.e2
  3. Larsen TR, Gelaye A, Durando C. Acute warfarin toxicity: An unanticipated consequence of amoxicillin/clavulanate administration. Am J Case Rep. 2014 Jan 27; 15: 45-8.
  4. Jacobs A, Bassa F, Decloedt EH. A preliminary review of warfarin toxicity in a tertiary hospital in Cape Town, South Africa. Cardiovasc J Afr. 2017 Nov/Dec 23; 28(6):
    346-9.
  5. Sayal KS, Duncan-McConnell DA, McConnell HW, Taylor DM. Psychotropic interactions with warfarin. Acta Psychiatr Scand. 2000 Oct;102(4):250-5.
  6. Howard-Thompson A, Hurdle AC, Arnold LB, Finch CK, Sands C, Self TH. Intracerebral hemorrhage secondary to a warfarin-metronidazole interaction. Am J Geriatr Pharmacother. 2008 Mar; 6(1):33-6.

 

 

Journal of Patient Safety & Quality Improvement
Volume 7, Issue 4
October 2019
Pages 181-183

Files

Share

How to cite

Statistics