Leukocytosis in Diabetic Ketoacidosis; Whether the Time Has Come to Start Antibiotics? A Short Literature Review

Document Type : Letter to the editor


1 Department of Nursing, Esfarayen Faculty of Medical Sciences, Esfarayen, Iran.

2 Department of Nursing,Esfarayen Faculty of Medical Sciences, Esfarayen, Iran.

3 Department of Basic Sciences, Esfarayen Faculty of Medical Sciences, Esfarayen, Iran.


No Abstract is available


1- Dhatariya K. Diabetic ketoacidosis and hyperosmolar crisis in adults. Medicine.2014; 42(12):723-6. 
2- Realsen J, Goettle H, Chase HP. Morbidity and mortality of diabetic ketoacidosis with and without insulin pump care. Diabetes Technol Ther. 2012; 14(12):1149-54. 
3- Maskey R, Shakya DR, Nikesh B, Krishna KA, Lavaju P, Kattel V, et al. Clinical profile of diabetic ketoacidosis in tertiary care hospital of Eastern Nepal. Indian J Endocrinol Metab.2015; 19(5):673-5. 
4- Cheng YC, Huang CH, Lin WR, Lu PL, Chang K, Tsai JJ, et al. Clinical outcomes of septic patients with diabetic ketoacidosis between 2004 and 2013 in a tertiary hospital in Taiwan. J Microbiol Immunol Infect. 2014;49(5):663-71. 
5- Esmailzadeh A, Zarrinfar H, Fata A, Sen T. High prevalence of candiduria due to nonalbicans Candida species among diabetic patients: a matter of concern? J Clin Lab Anal. 2018; 32(4):e22343. 
6- Honda T, Uehara T, Matsumoto G, Arai S,Sugano M. Neutrophil left shift and whiteblood cell count as markers of bacterialinfection. Clin Chim Acta. 2016; 457:46-53. 
7- Klouwens MJ, Blok WL, Witmer AN,Verouden CJ, Mura M. Serious complicationsof urinary tract infection in diabetes:emphysematous pyelonephritis and endogenous endophthalmitis. Ned TijdschrGeneeskd. 2013; 157(7):A5243. 
8- Antibiotic resistance threats in the United States, 2013. Atlanta, GA: US Department ofHealth and Human Services, CDC; 2013.  
9- Karavanaki K, Kakleas K, Georga S,Bartzeliotou A, Mavropoulos G, Tsouvalas M,et al. Plasma high sensitivity C-reactive protein and its relationship with cytokinelevels in children with newly diagnosed type1 diabetes and ketoacidosis. Clin Biochem.2012; 45(16-17):1383-8. 
10- Xu W, Wu HF, Ma SG, Bai F, Hu W, Jin Y, et al. Correlation between peripheral white blood cell counts and hyperglycemic emergencies.Int J Med Sci. 2013; 10(6):758-65.
11- Gillani SW, Sulaiman SA, Sundram S. Prediction and rate of infections in diabetesmellitus patients with diabetes ketoacidosisin Penang, Malaysia. Open J Epidemiol. 2012;2(1):1.  
12- Kayashima T, Yamaguchi K, Akiyoshi T,Nanimatsu H, Aragaki S, Hosokawa T.Leukemoid reaction associated with diabeticketoacidosis--with measurement of plasmalevels of granulocyte colony-stimulatingfactor. Intern Med. 1993; 32(11):869-71. 
13- Moradi S, Kerman SR, Rohani F, Salari F.Association between diabetes complicationsand leukocyte counts in Iranian patients. JInflam Res. 2012; 5:7-11. 
14- Karavanaki K, Karanika E, Georga S,Bartzeliotou A, Tsouvalas M, KonstantopoulosI, et al. Cytokine response to diabeticketoacidosis (DKA) in children with type 1diabetes (T1DM). Endocr J. 2011; 58(12):1045-53.