Document Type : Original Article
Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Research Center for Patient Safety, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Pediatric Immunology and Allergy, Mashhad University of Medical Sciences, Mashhad, Iran
Biological Sciences Student, California State University, East Bay, Hayward, California
Introduction: To investigate the value of procalcitonin (PCT) in lobar and non-lobar pneumonia in children.
Materials and Methods: 80 children with pneumonia were included. 20 healthy children were selected as control. Lobar and non-lobar pneumonia were recognized. The serum level of C reactive protein (CRP), erythrocyte sedimentation rate (ESR), leukocytes and PCT were measured. Statistical analysis was performed using SPSS windows program.
Results: Among the 80 children 39 cases (48.75%) were female and 41 cases (51.25%) were male with the average of 17.29±2.43 months. 7 patients (8.75%) were diagnosed with lobar pneumonia. Cough, tachypnea and Crackles were more common symptoms in lobar pneumonic patients. Leukocytosis (more than 15000/microliter) was more prominent in pneumonic patients versus control as well as lobar pneumonia versus non-lobar (p<0.05). The CRP with 3+ level was prominent in lobar pneumonic patients (p=0.02). The mean of ESR in lobar group was higher than non-lobar group (p=0.001). The PCT level of 2ng/mL could consider as cut off point of lobar and non-lobar pneumonia. The PCT level of 0.5ng/mL could consider as cut off point between pneumonic and healthy children.
Conclusion: Serum level of PCT is higher in lobar pneumonia than non-lobar pneumonia in children with cut off point of 2ng/mL.