Introduction: Helicobacter pylori (H.pylori) is the most common chronic worldwide bacterial infection in humans in all of ages and  the majority of Chronic Urticarial patients also carry     H. Pylori. The purpose of the present study was to studied H. pylori eradication in the treatment of chronic urticaria in comparison with classic treatment on two treatment groups.
Materials & Methods: participants were 120 Chronic Urticaria patients with H. Pylori infected and positive Urease Breath Test (UBT) who refer to Quaem Hospital in Mashhad. Participants were randomly assigned two groups, control group received classic treatment of Urticaria (H1 & H2 Blockers) and investigation group was additional treatment by triple drug therapy (20 mg of Robeprazole twice daily, 500 mg of Clarithromycin twice daily, and 1gr of Amoxicillin twice daily during 14 days). Within one, three & six months after therapy symptoms were separately analyzed in two groups by using urticaria severity score.
Results: As to the age factor, no significant difference was found (P-value: 0.863). However, the average age with regard to gender, was significantly higher in men (P-value: 0.006).The majority of patients who had been exposed to combination drug treatment, were significantly better cured than the group exposed to classic treatment lonely (P-value < 0.001) and many components of urticaria severity score showed better improvement respectively (P-value < 0.001).
Conclusions: Addition of this treatment for eradication of Helicobacter pylori infection in patients with chronic urticaria, could be more effective than the classic H1and H2 blockers alone for resolution of symptoms.