@article { author = {Saberi, Marzieh and Tavanaii sani, Ashraf}, title = {HIV-1/HTLV Co-Infection: a Survey of Molecular Basis with Clinical Studies}, journal = {Journal of Patient Safety & Quality Improvement}, volume = {5}, number = {1}, pages = {497-501}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-4482}, eissn = {2345-4490}, doi = {10.22038/psj.2017.9739.1093}, abstract = {Human immunodeficiency virus type-1 (HIV–1) and human T-cell leukemia virus (HIV-1/HTLV) co-infection is a serious health problem worldwide, especially in endemic areas and vulnerable subjects like intravenous drug abusers. This is due to the fact that CD4+ and CD8+ T-cells are the primary targets of HTLV-1 and HTLV-2, respectively. The influence of HTLV-1 and HTLV-2 on CD4+ count can shortened or prolong progression to AIDS and the development of more clinical complications. Opportunistic infections may differ between HIV-1/HTLV-1 and HIV-1/HTLV-2 co-infection subjects. Several epidemiologic studies have discussed molecular bases of HIV-1/HTLV co-infection, including cytokine and chemokine mediated pathways; however, they have yielded discrepant results.}, keywords = {Co-infection,HIV,HTLV-1}, url = {https://psj.mums.ac.ir/article_8161.html}, eprint = {https://psj.mums.ac.ir/article_8161_c90dee389030ac18073bef0d06d5ed24.pdf} }