Predictive Role of Diastolic Echocardiographic Findings in the Outcome of Heart Failure with Preserved Ejection Fraction

Document Type: Review Article


Patient Safety Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


The main predictors of Heart Failure with preserved Ejection Fraction (HFpEF) are increased systolic blood pressure, atrial fibrillation, and female gender. Heart Failure (HF) with reduced Ejection Fraction (EF) is associated with prior myocardial infarction and left bundle-branch block QRS morphology. This study aimed to evaluate the effect of diastolic echocardiographic findings on the outcome of patients with HFpEF.
This systematic review was conducted via searching in databases such as Cochrane Library and MEDLINE until September 2015, and articles with available abstracts published in English were included in the study. Manual search was performed within the reference lists of the articles. Moreover, two reviewers independently assessed the inclusion criteria, quality and extracted data of the selected articles.
In total, four articles were evaluated in this systematic review, with the earliest study published in 2007 and the most recent article published in 2015.
According to the results of this review, Doppler echocardiography plays a pivotal role in the assessment of diastolic left ventricular filling dynamics. However, this technique is restricted by the confounding effects of the changes in the heart rate and loading conditions.